Clear Cell (Tubulo) Papillary Renal Cell Carcinoma: A Case Report and Literature Review of a Recently Recognized New Entity

Adrienne Sauder, Zena Jameel, Charvi Patel, Andrew Golden, Shahida Ahmed, Jin Choe, Donghong Cai

Abstract


Clear cell (tubulo) papillary renal cell carcinoma (CCPRCC) is a newly established entity in renal tumor classification. Here we report a case of CCPRCC in a 61 year old male with long history of hypertension, chronic renal failure, and one year history of dialysis. Grossly the tumor is multicystic. Microscopically, bland appearing tubules and occasional small papillae with low grade nuclei are noted. The characteristic linear arrangement of nuclei deviating from basal aspect of the lumens is prominent. Immunohistochemically, the tumor cells are positive for CK7, high-molecular weight cytokeratin (HMWK), CA-IX (cup-shape pattern), and negative for AMACR and CD10. The histology and immunophenotype all qualify this tumor as CCPRCC. The diagnostic criteria and the related differential diagnoses are also discussed. 


Keywords


clear cell (tubule) papillary renal cell carcinoma, diagnostic criteria, immunophenotype, cup-shape pattern of CA-IX

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References


Srigley JR, Delahunt B, Eble JN, et al. The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. Am J Surg Pathol. 2013;37:1469-1489.

Tickoo SK and Reuter VE. Differential diagnosis of renal tumors with papillary architecture. Adv Anat Pathol. 2011;18:120-132.

Bhatnagar R, Alexiev BA. Renal-cell carcinomas in end-stage kidneys: a clinicopathological study with emphasis on clear-cell papillary renal-cell carcinoma and acquired cystic kidney disease-associated carcinoma. Int J Surg Pathol. 2012;20:19-28.

Aydin H, Chen L, Cheng L, et al. Clear cell tubulopapillary renal cell carcinoma: a study of 36 distinctive low-grade epithelial tumors of the kidney. Am J Surg Pathol. 2010;34:1608-1621.

Crumley SM, Divatia M, Truong L, Shen S, Ayala AG, Ro JY. Renal cell carcinoma: Evolving and emerging subtypes. World I Clin Cases. 2013;1:262-275.

Gobbo S, Eble JN, Grignon DJ, et al. Clear cell papillary renal cell carcinoma: a distinct histopathologic and molecular genetic entity. Am J Surg Pathol. 2008;32:1239-1245.

Tickoo SK, dePeralta-Venturina MN, Harik LR, et al. Spectrum of epithelial neoplasms in end-stage renal disease: an experience from 66 tumor-bearing kidneys with emphasis on histologic patterns distinct from those in sporadic adult renal neoplasia. Am J Surg Pathol. 2006;30:141-153.

Kuroda N, Hosokawa T, Michal M, et al. Clear cell renal cell carcinoma with focal renal angiomyoadenomatous tumor-like area. Ann Diagn Pathol. 2011;15:202-206.

Rohan SM, Xiao Y, Liang Y, et al. Clear-cell papillary renal cell carcinoma: molecular and immunohistochemical analysis with emphasis on the von Hippel-Lindau gene and hypoxia-inducible factor pathway-related proteins. Mod Pathol. 2011;24:1207-1220.

Adam J, Couturier J, Molinie V, Vieillefond A, Sibony M. Clear-cell papillary renal cell carcinoma: 24 cases of a distinct low-grade renal tumour and a comparative genomic hybridization array study of seven cases. Histopathology. 2011;58:1064-1071.

Williamson SR, Eble JN, Cheng L, Grignon DJ. Clear cell papillary renal cell carcinoma: differential diagnosis and extended immunohistochemical profile. Mod Pathol. 2013;26:697-708.

Brannon AR, Haake SM, Hacker KE, et al. Meta-analysis of clear cell renal cell carcinoma gene expression defines a variant subgroup and identifies gender influences on tumor biology. Eur Urol. 2012;61:258-268.


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