Histopathological Features of Aneurysmal Bone Cyst of the Temporal Bone – A Case Report and Review of Literature

Authors

  • Shiquan Liu Department of Medicine, Montefiore Mount Vernon Hospital, Mount Vernon, NY
  • Ali Jassim Department of Pathology, 3Medical Oncology/Hematology, State University of New York, Buffalo, NY
  • Jonathan Bleeker Sanford School of Medicine, University of South Dakota, State University of New York, Buffalo, NY
  • Frank Chen Department of Pathology, Buffalo General Medical Center, State University of New York, Buffalo, NY
  • Bangaruraj Kolanuvada Department of Medicine, Montefiore Mount Vernon Hospital, Mount Vernon, NY
  • Rong Rong Department of Pathology, Buffalo General Medical Center, State University of New York, Buffalo, NY
  • Weiguo Liu Department of Pathology, Buffalo General Medical Center, State University of New York, Buffalo, NY

Keywords:

aneurysmal bone cyst (ABC), temporal bone, bony trabeculae

Abstract

Aneurysmal bone cyst (ABC) is a rare lesion. We described an ABC of the temporal bone. The patient was a 46-year-old woman presenting with a progressively enlarging mass in the left temporal region with unknown duration. A CT revealed a 3 x 3.5 cm osteolytic lesion involving the left temporal bone. MRI revealed a 3.6 x 2.6 x 2.7 cm well-defined expansile lesion centered in the left temporal bone. The patient subsequently underwent MRI-guided stereotactic left frontotemporoparietal craniectomy and the lesion was completely removed. Following surgery, the patient has been followed for the past 9 months without evidence of residual/recurrent disease. Morphologically, the lesion consisted of cystic and solid areas. The cystic areas demonstrate multi-cystic architecture between bony trabeculae separated by thick septa. These septa contained abundant fibroblasts, spindle-shaped stromal cells, and giant cells with scattered hemosiderin laden macrophages. The solid areas consisted of spindle-shaped stromal cells with oval nuclei, proliferating blood vessels, mononuclear cells and some interspersed multinucleated giant cells.

References

1. Gan YC, Hockley AD. Aneurysmal bone cysts of the cranium in children-Report of three cases and brief review of the literature. J Neurosurg. 2007;106:401-406.
2. Park AH, Phillips J, Forte V. Aneurysmal bone cyst of the temporal bone. Otolaryngol Head Neck Surg. 1999;120:606-610.
3. Fiegenberg SJ, Marcus RB, Zlotecki RA, Scarborough MT, Berrey BH, Enneking WF. Megavoltage radiotherapy for aneurysmal bone cysts. Int J Rad Oncol. 2001;49:1243-1247.
4. Sawin PD, Muhonen MG, Sato Y, Smith RJ. Aneurysmal bone cyst of the temporal bone presenting as hearing loss in a child. Int J Pediatr Otorhinolaryngol. 1995;33:275-284.
5. Yu JW, Kim KU, Kim SJ, Choi S. Aneurysmal bone cyst of the orbit : a case report with literature review. J Korean Neurosurg Soc. 2012;51:113-116.
6. Jaffe HL, Lichtenstein L. Solitary unicameral bone cyst with emphasis on the roentgen picture, the pathological appearance and the pathogenesis. Arch Surg. 1942;44:1004-1025.
7. Citardi MJ, Janjua T, Abrahams JJ, Sasaki CT. Orbitoethmoid aneurysmal bone cyst. Otolaryngol Head Neck Surg. 1996;114:466-470.
8. Senol U, Karaali K, Akyüz M, Gelen T, Tuncer R, Lüleci E. Aneurysmal bone cyst of the orbit. AJNR Am J Neuroradiol. 2002;23:319-321.
9. Martinez V, Sissons HA. Aneurysmal bone cyst. A review of 123 cases including primary lesions and those secondary to other bone pathology. Cancer. 1988;61:2291-2304
10. Cansiz H, Inci E, Erisir F, et al. Aneurysmal bone cyst of the sphenoid bone. J Craniofac Surg. 2002;13:411-414.
11. Sabatini PR, Horenstein MG, Oliveri CV, Gacek RR. Aneurysmal bone cyst of the temporal bone associated with reversible hemifacial paralysis. Am J Otolaryngol. 2005;26:261-264.
12. Buxi TB, Sud S, Vohra R, Sud A, Singh S. Aneurysmal bone cyst of the temporal bone. Australas Radiol. 2004;48:251-255.
13. Panoutsakopoulos G, Pandis N, Kyriazoglou I, Gustafson P, Mertens F, Mandahl N. Recurrent t(16;17)(q22;p13) in aneurysmal bone cysts. Genes Chromosomes Cancer. 1999;26:265-266.
14. Herens C, Thiry A, Dresse MF, et al. Translocation (16;17)(q22;p13) is a recurrent anomaly of aneurysmal bone cysts. Cancer Genet Cytogenet. 2001;127:83-84.
15. Purohit A, Chopra S, Sinha VD, Dharker SR. Aneurysmal bone cyst of the temporal bone: a case report. Neurol India. 2002;50:511-513.
16. Goyal A, Tyagi I, Syal R, Agrawal T, Jain M. Primary aneurysmal bone cyst of coronoid process. BMC Ear Nose Throat Disord. 2006;14:4.
17. Chidambaram B, Santosh V, Balasubramaniam V. Aneurysmal bone cyst of the temporal bone. Childs Nerv Syst. 2001;17:411-414.
18. Oliveira AM, Perez-Atayde AR, Inwards CY, et al. USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. Am J Pathol. 2004;165:1773-1780.
19. Lau AW, Pringle LM, Quick L, et al. TRE17/ubiquitin-specific protease 6 (USP6) oncogene translocated in aneurysmal bone cyst blocks osteoblastic maturation via an autocrine mechanism involving bone morphogenetic protein dysregulation. J Biol Chem. 2010;285:37111-37120.

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Published

2015-01-25

How to Cite

Liu, S., Jassim, A., Bleeker, J., Chen, F., Kolanuvada, B., Rong, R., & Liu, W. (2015). Histopathological Features of Aneurysmal Bone Cyst of the Temporal Bone – A Case Report and Review of Literature. North American Journal of Medicine and Science, 8(1). Retrieved from https://www.najms.com/index.php/najms/article/view/33

Issue

Vol. 8 No. 1 (2015)

Section

Case Report