Malignant Pleural Effusion, an Unusual Presentation of Metastatic Adenoid Cystic Carcinoma: A Case Report and Review of the Literature
Abstract
Adenoid cystic carcinoma (ACC) is an uncommon malignant neoplasm of the major and minor salivary glands that is known to have a long clinical course, behaving in an insidious and indolent fashion with multiple recurrences preceding distant metastasis. Reported here is a case of a patient presenting with shortness of breath and recurrent pleural effusion. Exfoliated ACC cells were observed on cytological evaluation, a rare occurrence. Mediastinal lymph node involvement was also confirmed on cytology. A primary site of origin was not found. In summary ACC can present in various body sites and pathologists should consider ACC in the differential diagnosis of a basaloid carcinoma of uncertain origin.
[N A J Med Sci. 2017;10(1):8-12. DOI: 10.7156/najms.2017.1001008]
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Mitra S, Kundu S, Pattari SK, et al. Metastatic Pleural effusion: A rare presentation of salivary gland adenoid cystic carcinoma. Indian Journal of Chest Dis. Allied Sci. 2011;53:107-110.
Florentine BD, Fink T, Avidan S, et al. Extra Salivary gland presentations of Adenoid Cystic carcinoma: A report of Three cases. Diagn Cytopathol. 2006 ;34:491-494.
Bradley PJ. Adenoid cystic carcinoma of the head and neck: A review. Curr Opin Otolaryngol Head and Neck Surg. 2004;12:127-132.
Adenoid Cystic Carcinoma of the Lung. http://www.dovemed.com/adenoid-cystic-carcinoma-of-the-lung/
Wenig, BM ed. Atlas of Head and Neck Pathology; 2nd Ed. New York, NY: Elsevier, Publisher; 2016.
Kitada M, Ozawa K, Sato K, et al. Adenoid Cystic carcinoma of the peripheral lung: A case report. World J Surg Oncol. 2010;8:74.
Moran CA, Suster S, Koss MN. Primary Adenoid Cystic carcinoma of the lung. A clinicopathologic and Immunohistochemical study of 16 cases. Cancer. 1994;73:1390-1397.
Giannini PJ, Shetty KV, Horan SL, et al. Adenoid cystic carcinoma of the buccal vestibule: Case report and review of the literature. Oral Oncology. 2006;42:1029-1032.
Hu M, Hu Y, He J, et al. Primary adenoid cystic carcinoma of the lung: Clinicopathologic features, treatment and results. Oncol Lett. 2015;9:1475-1481.
Triantafillidou K, Dimitrakopoulos J, Iordanidis F, et al. Management of Adenoid Cystic carcinoma of minor salivary glands. J Oral Maxillofac Surg. 2006;64:1114-1120.
Ko YH, Lee MA, Hong YS, et al. Prognostic factors affecting the clinical outcome of Adenoid Cystic Carcinoma of the Head and Neck. Jpn J Clin Oncol. 2007;37:805-811.
Torre W, Comellas M, Cuesta M. Massive pleural effusion an isolated manifestation of metastatic spread of salivary adenoid cystic carcinoma. Respir Med. 1997;91:169-170.
Sur RK, Donde B, Levin V, et al. Adenoid Cystic carcinoma of the salivary glands: A review of 10 years. Laryngoscope. 1997;107:1276-1280.
Zhu F, Liu Z, Hou Y, et al. Primary Salivary Gland-Type Lung cancer-Clinicopathologic analysis of 88 cases from China. J Thorac Oncol. 2013;8:1578-1584.
Lin C-M, Li A F.-Y, Wu L.-H, et al. Adenoid Cystic Carcinoma of the trachea and bronchus-a clinicopathologic study with DNA flow cytometric analysis and oncogene expression. Eur J Cardiothorac Surg. 2002;22:621-625.
Spiro RH. Distant Metastasis in Adenoid Cystic carcinoma of salivary gland origin. Am J Surg. 1997;174:495-498.
Locati LD, Guzzo M, Bossi P, et al. Lung metastasectomy in adenoid cystic carcinoma (ACC) of salivary gland. Oral Oncology. 2005;41:890-894.
Perzin KH, Gullan P, Clairmont AC. Adenoid Cystic carcinoma arising in salivary glands: a correlation of histologic features and clinical course. Cancer. 1978;42:265-282.
Maziak DE, Todd TRJ, Keshavji SH, et al. Adenoid Cystic carcinoma of the airway: Thirty-two-year experience. J Thorac Cardiovasc Surg. 1996;112:1522-1532.
Spiro RH, Huvos AG, Strong EW. Adenoid cystic carcinoma: factors influencing survival. Am J of Surg. 1979;138:570-583.
Min R, Siyi L, Wenjun Y, et al. Salivary gland adenoid cystic carcinoma with cervical lymph node metastasis: a preliminary study of 62 cases. Int J Oral Maxillofac Surg. 2012;41:952-957.
Stell PM, Cruickshank AH, Stoney PJ, et al. Lymph node metastasis in Adenoid Cystic carcinoma. Am J Otolayngol. 1985;6:433-436.
Allen A, Rabin M, Reilly J, et al. Unresectable adenoid cystic carcinoma of the Trachea treated with chemoradiation. J Clin Oncol. 2007;25:5521-5523.
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