Ducts of Luschka as a Mimicker of Well-Differentiated Adenocarcinoma of Gallbladder: A Case Report and Review of Literature

Jing He, MD, Zhenjian Cai, MD, PhD, Hui Zhu, MD, PhD

Abstract


Ducts of Luschka are small bile ducts located at the subserosal or subhepatic connective tissue of gallbladder. These ducts are commonly seen in up to 10% of routine cholecystectomy specimens. When proliferating with reactive changes as seen in the background of acute cholecystitis, they can mimic adenocarcinoma of gallbladder. However, this phenomenon is not well recognized in pathology literature, with only two articles available in English language literature. In this study, we report a case of acute cholecystitis with reactive Ducts of Luschka that is difficult to distinguish from gallbladder adenocarcinoma. We described the clinical and pathologic findings in this case and discussed the morphologic features that are helpful in establishing the correct diagnosis.

[N A J Med Sci. 2016;9(4):187-191.   DOI:  10.7156/najms.2016.0904187]

Key Words: ducts of Luschka, gallbladder adenocarcinoma


Keywords


ducts of Luschka, gallbladder adenocarcinoma

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References


Singhi AD, Adsay NV, Swierczynski SL, et al. Hyperplastic Luschka Ducts: A Mimic of Adenocarcinoma in the Gallbladder Fossa. Am J Surg Pathol. 2011;35:883–890.

Rajab R, Meara N, Chang F. Florid ducts of Luschka mimicking a well differentiated adenocarcinoma of the gallbladder. The Int J pathology. 2007;6:360-365.

Odze RD, Goldblum JR. Odze, Goldblum Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas. 3rd edition. Elsevier; 2014

Sharif K, de Ville de Goyet J. Bile duct of Luschka leading to bile leak after cholecystectomy - revisiting the biliary anatomy. J Pediatr Surg 2003;38:21-23.

Jahan M, Xiao P, Go A, Cheema M, Hameed A. Intraductal and invasive adenocarcinoma of duct of Luschka, mimicking chornic cholecystitis and cholelithiasis. World Journal of Surgical Oncology. 2009;7:4.

Mori S, Kasahara M: Papillary adenocarcinoma of the subvesical duct. J Hepatobiliary Pancrat Surg 2001;8:494-498.

Stacey E. Milles. Histology for pathologists. 4th edition. Lippincott Williams & Wilkins; 2012

Priya TP, Kapoor VK, Krishnani N, et al. Fragile histidine triad (FHIT) gene and its association with p53 protein expression in the progression of gallbladder cancer. Cancer research 2009;26:764-773.

Tang ZH, Zou SQ, Wang BJ, et al. The relationship between loss expression of DPC4/Smad4 gene and carcinogenesis ofpancreatobiliary carcinoma. Hepatobiliary Pancreat Dis Int. 2002;1:624-629.


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